“Using Prizes to Spur Open Innovation”: The National Institutes of Health (NIH) Explore Potential Approaches

This week’s NIH conference “Crowdsourcing: The Art and Science of Open Innovation” could be a hint that the research agency is seriously considering new ways to take advantage of the “processing power of lots of willing brains”.

ScienceInsider published a summary report that states:

NIH Director Francis Collins would soon sign papers that would ensure NIH is compliant with the America COMPETES Act, which gives federal agencies the authority to offer cash incentives for researchers to tackle high-risk, high-reward research questions that have eluded more traditional funding platforms, such as grants and sponsored research.

The America COMPETES Act was first passed in 2007 and was reauthorized in December. Under its authority, federal agencies outline a problem they’d like solved on Challenge.gov, then open the competition to individuals or teams, evaluate the results, and award a money prize to whoever turns in the best solution.


Blogging about peer-reviewed research

The aptly-named Research Blogging service aggregates blog posts about peer-reviewed research.They scan supported blogs for references to published papers, aggregating the content, and supporting structured links to references. While the tagging and citation addition process seems still a bit too manual and brittle for my tastes, it’s clearly scaled, with bloggers publishing about 17 posts a day in 7 supported languages.

Research Blogging looks like a great way to explore post-publication review and discussion—but would they open up their data so that it can be mashed up by third parties? Imagine being able to read a publication, and see not only articles that cite it, but blog posts as well.

Read more:

LabLife.org – A Model for a Future Research Portal at CTSI, and perhaps even UCSF?

This site is interesting because it helps researchers perform a variety of tasks and supports their online community. At the same time, it provides clear paths to access more information without overwhelming the user. And btw, the goal of the site is easily comprehensible.

LabLife is free for academic labs. We recently learned that UCSF postdocs are using it frequently. And they’re not the only ones, according to LabLife over 1800 labs from 1200 institutions world-wide are using the site.

Here are a few examples how the site supports several aspects of a researcher’s lab life:

  • searching for products,
  • coordinating purchases (preventing ordering mistakes),
  • managing (tracking) reagents, documents, and data,
  • searching for jobs and publications, and
  • sharing information with colleagues and the community.

What do you think?

Google Pulls the Plug on Google Health

From the  announcement on the Google blog:

“When we launched Google Health, our goal was to create a service that would give people access to their personal health and wellness information. We wanted to translate our successful consumer-centered approach from other domains to healthcare and have a real impact on the day-to-day health experiences of millions of our users.

Now, with a few years of experience, we’ve observed that Google Health is not having the broad impact that we hoped it would. There has been adoption among certain groups of users like tech-savvy patients and their caregivers, and more recently fitness and wellness enthusiasts. But we haven’t found a way to translate that limited usage into widespread adoption in the daily health routines of millions of people. That’s why we’ve made the difficult decision to discontinue the Google Health service. We’ll continue to operate the Google Health site as usual through January 1, 2012, and we’ll provide an ongoing way for people to download their health data for an additional year beyond that, through January 1, 2013. Any data that remains in Google Health after that point will be permanently deleted.”

Also check out the TechCrunch story.

Cigarette warning labels around the world

The FDA’s new cigarette warning labels have been getting a lot of buzz, underscoring the role of design in public health communication. The new designs take up half the cigarette pack, and 20% of the size of ads. According to the Wall Street Journal, the FDA estimates that the design will reduce the number of smokers by over 200,000 in the first year after launch, based on the impact of new warning labels in Canada.

Cigarette Health Warning ImagesCigarette Health Warning ImagesCigarette Health Warning ImagesCigarette Health Warning Images

There are a variety of approaches to tobacco packaging warnings, but bold graphic warnings are clearly the emerging international consensus. Here are some examples from around the world:

Brazil:
Cigarette warning labels

Thailand:
Gruesome

Click to see more…

Pfizer Announces First U.S. “Virtual” Clinical Trial Allowing Patients to Participate Regardless Of Geography

The randomized pilot study, called REMOTE, uses mobile phone and web-based technology (e.g. electronic diaries, online testing tools, a dedicated website) to collect the necessary data for the trial without clinic visits.

Investigators plan to enroll about 600 patients from about 10 states across the United States. Pfizer will compare results to previous clinical trials and assess whether virtual trials can save time and obtain the same results as traditional ones, or perhaps even more reliable data through increased patient compliance, lower withdrawal rates and real-time data collection.

Although not all clinical trials could be done remotely, if this pilot proves successful, it might be an interesting model for our emerging UCSF-CTSI Participant Recruitment Service.

Watch the animated video that outlines the trial’s basics to patients

More information:

Wired magazine on open publishing

Biologist Howard Eisen's son tries to put his late father's papers freely online. Hilarity ensues.

Trying to explain open publishing to someone outside the field? “Free Science, One Paper at a Time” in the May Wired tells a compelling story about the need for open publishing, referencing PLoS, academic librarians’ woes, Mendeley, and Michael Weiner’s work on ADNI, through the story of Jonathan Eisen‘s attempt to make his late father’s scientific publications freely accessible online. Very readable, and highly recommended.

Read more…

Upcoming talk on Open Science by Michael Nielsen

For those of us interested in open science, Dr. Michael Nielsen will be speaking in San Francisco later this month.  Dr. Nielsen is a leading advocate in this field and his book, “Reinventing Discovery” will be published later this year.  Here’s some information about his upcoming talk:

The net is transforming many aspects of our society, from finance to friendship.  And yet scientists, who helped create the net, are extremely conservative in how they use it.  Although the net has great potential to transform science, most scientists remain stuck in a centuries-old system for the construction of knowledge. Michael will describe some leading-edge projects that show how online tools can radically change and improve science using projects in Mathematics and Citizen Science as examples, and he will then go on to discuss why these tools haven’t spread to all corners of science, and how we can change that. [via]

The wine, beer, and cheese event will be held at the Public Library of Science on June 29th at 6pm.  The event is free and open to the public,but they ask people to RSVP at rshah@plos.org if you plan to attend.

Industry embraces the semantic web! Just like us, only different….

Google, Bing!, and Yahoo announced an initiative on June 2, 2011 to create Schema.org, a web site that will promote standard ways of adding machine readable (semantic) data to all of our web pages.  As a validation of the semantic web, this is great news.

However, they are supporting a different format for exposing semantic data than what we use in biomedical informatics, so what does that mean for our way of doing things?  More specifically, we have become proponents of RDFa as the “serialization format” for exposing our semantic data. RDFa is how VIVO exposes semantic data, it’s how the future versions (and current Harvard version) of Profiles will expose semantic data, and it’s intrinsically tied to our support of machine readable ontologies such as vivo and foaf.

Schema.org will support a different serialization format known as “microdata”.  Some are seeing this as the possible death of RDFa: http://graveshow.com/blog/tutorials/web-design/death-rdfa.  Others are not sure if it is a threat or opportunity: http://bnode.org/blog/2011/06/06/schema-org-threat-or-opportunity.  At least one person thinks this is actually good for RDFa: http://planet.linkeddata.org/.  The schema.org creators are aware of the controversy they have created with their support of microdata versus RDFa, and they do a good job of explaining their decisions here: http://schema.org/docs/faq.html.

The general consensus seems to be that RDFa is in many ways a more complete solution for semantic expression than microdata, but RDFa is difficult and intimidating for developers to grasp and therefore suffers from adoption outside of certain niche fields (such as BioMed2.0). We don’t mind handling the difficulty of RDFa because our field has already forced us to deal with the challenges of sharing large complex data sets and to wrap our heads around ontologies and other semantic concepts.

One way to interpret this would be to say that what we are doing with the semantic web in BioMed is great, and that we should continue down our path while industry takes a baby step into the semantic web with the more-pragmatic if less-complete microdata approach.  At the surface, this would seem like a fine solution.  The problem is: now we have industry and BioMed on different paths.  For those people (like us at UCSF) who want to combine the best technical solutions from industry with the best technical solutions of academia and research, this can be a problem.

In particular at UCSF we want to combine our “academic” BioMed semantic web solutions with the “industry” OpenSocial specification to create something that is a better way to publish and share data rich applications than either one of those technologies can support by themselves today.  In pursuing this we’re already seeing issues with bridging RDFa into the JSON centric world of OpenSocial.  Mapping RDFa to JSON is a tough problem to solve, and a number of solutions have been proposed (search RDFa and JSON) without any clear winner.  However with microdata, going from semantic web to JSON/OpenSocial might not be as hard.  Given industries favor of pragmatism over elegance, and the recognition that JSON is THE dominant data exchange method on the web today, this would hardly be surprising.  So…., for some of us this “support of the semantic web & simultaneous challenge to RDFa” may be good news after all!

Now we just need to deal with the very real problem of getting VIVO, Profiles and the rest of our BioMed2.0 systems to produce microdata as well as RDFa.  And why not?  Supporting one format, even by mandate, does not mean you shouldn’t support another.  If you want to share data and ideas, which we say we want to do, then the more the merrier.